Proteins 1: Protein Fundamentals (BCMB 30400).  The course covers the physico chemical phenomena that define protein structure and function.  Topics include:  1) the interactions/forces that define polypeptide conformation; 2) the principles of protein folding, structure and design; and 3) the concepts of molecular motion, molecular recognition, and enzyme catalysis.  Prereq:  BCMB 30100, which may be taken concurrently, or equivalent.  Koide, Keenan.  Autumn.

Fundamentals of Structural Biology (BCMB 30500).  This course emphasizes the basic principles of protein structure determination by X-ray crystallography and NMR spectroscopy. The underlying physical concepts of these methods will be introduced and the capabilities of each will be discussed and compared in context of their uses in de novo structure determination and protein engineering studies.  Kossiakoff, Koide.  Winter.  (This course will not be offered in 2008.)

Proteins 2: Structure and Function of Membrane Proteins (BCMB 32300).  This course will be an in depth assessment of the structure and function of biological membranes. In addition to lectures, directed discussions of papers from the literature will be used. The main topics of the courses are: (1) Energetic and thermodynamic principles associated with membrane formation, stability and solute transport (2) membrane protein structure, (3) lipid-protein interactions, (4) bioenergetics and transmembrane transportmechanisms, and (5) specific examples of membrane protein systems and their function (channels, transporters, pumps, receptors). Emphasis will be placed on biophysical approaches in these areas. The primary literature will be the main source of reading.  Perozo, Roux.  Winter

Cell Biology 1 (MGCB 31600).  Eukaryotic protein traffic and related topics, including molecular motors and cytoskeletal dynamics, organelle architecture and biogenesis, protein translocationand sorting, compartmentalization in the secretory pathway, endocytosis and exocytosis,and mechanisms and regulation of membrane fusion.  Glick, Turkewitz.  Autumn.

Cell Biology 2 (MGCB 31700).
This course will cover cell cycle progression, cell growth, cell death, cytoskeletal polymers and motors, cell motility, and cell polarity.  Glotzer, Kovar.  Winter.

General Principles of Genetic Analysis (GENE 31400).  Coverage of the fundamental tools of genetic analysis as used to study biological phenomena. Topics include genetic exchange in prokaryotes and eukaryotes, analysis of gene function, and epigenetics.  Bishop and Staff.  Autumn.

Genetic Mechanisms (GENE 31500).  Advanced coverage of genetic mechanisms involved in genome stability and rearrangement in lower and higher organisms.  Topics include the genetics of mutagenesis, DNA repair, homologous and site specific recombination, transposition and chromosome segregation.  Bishop.  Winter.

Human Genetics 1: Human Genetics (HGEN 47000).  This course covers classical and modern approaches to studying cytogenetic, Mendelian, and complex human diseases.  Topics include chromosome biology, human gene discovery for single gene and complex disease, non-Mendelian inheritance, mouse models of human disease, cancer genetics, and human population genetics.  The format includes lectures and student presentations.  Cox, Millen, Ober.  Autumn.

Fundamentals in Molecular Biology (MGCB 31000).  The course covers nucleic acid structure and DNAtopology, recombinant DNA technology, DNA replication, DNA damage, mutagenesis and repair, Transposons and site-specific recombination, prokaryotic and eukaryotic transcription and its regulation, RNA structure, splicing and catalytic RNAs, protein synthesis, and chromatin.  Staley. Storb  Winter.

Molecular Biology 1 (MGCB 31200).
Nucleic acid structure and DNA topology; methodology; nucleic-acid protein interactions; mechanisms and regulation of transcription in eubacteria, and of replication in eubacteria and eukaryotes; mechanisms of genome and plasmid segregation in eubacteria.  Rothman-Denes.  Winter.

Molecular Biology 2 (MGCB 31300).
The content of this course will cover the mechanisms and regulation of eukaryotic gene expression at the transcriptional and post-transcriptional levels. Our goal is to explore with you research frontiers and evolving methodologies. Rather than focusing on the elemental aspects of a topic, the lectures and discussions will focus on the most significant recent developments, their implications and future directions. Singh, Staley.  Spring.