George Bakris, M.D.

Research Summary

Dr. George Bakris specializes in the diagnosis and reduction of high blood pressure, particularly in complicated or refractory cases. He is also skilled in the treatment of kidney disease, with special expertise in diabetes-related kidney disease.

In his research activities, Dr. Bakris explores why the rate of kidney disease is significantly higher in the black population than it is in other ethnic groups. He also evaluates specific genetic and other markers that determine progression and development of kidney disease, as well as heightened cardiovascular risk.

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Selected Papers

Zeiser R, Nguyen VH, Beihack A, Buess M, Schulz S, Baker J, Contag CH, Negrin RS. Inhibition of CD4+CD25+ regulatory T cell function by calcineurin dependent interleukin-2 production. Blood. 2006 Jul 1;108(1):390-9

Nguyen VH, Zeiser R, Negrin RS. Role of naturally arising regulatory T cells in hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2006 Oct;12(10):995-1009.

Zeiser R, Nguyen VH, Hou JZ, Beilhack A, Zambricki E, Buess M, Contag CH, Negrin RS. Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease. Blood. 2007 Mar 1;109(5):2225-33.

Nguyen VH, Zeiser R, daSilva D, Chang DS, Beilhack A, Contag CH, Negrin RS. In vivo dynamics of regulatory T cell trafficking and survival predict effective strategies to control of graft-versus-host disease following allogeneic transplantation. Blood 2007 Mar 15;109(6):2649-56

Nguyen VH, Shashidhar S, Chang DS, Ho L, Kambham N, Bachmann M, Brown JMY, Negrin RS. The impact of regulatory T cells on T cell immunity following hematopoeitic cell transplantation. Blood 2008 Jan 15;111(2):945-53

Nguyen Vu, van Besien Koen.  Late relapses following allogeneic transplantation for chronic lymphocytic leukemia.  How good are the graft-versus-leukemia effects?  Leukemia & Lymphoma  2008 Sept; 49(9): 1651-1652