|
Appointments:
Assistant Professor
Department of Medicine
Section of Pulmonary and Critical
Care Medicine
Committee on Molecular Medicine/MPMM
|
Education:
PhD, National Cardiology Research
Center, 1992
MD, Moscow State Medical School,
1986
|
Contact:
Phone: (773) 834-2636
Fax: (773)
834-2683
E-Mail:
kbirukov@medicine.bsd.uchicago.edu
Address:
The University of Chicago
GCIS W403K
929 East 57th Street
Chicago, Illinois 60637
|
Related Research Interests:
|
|
Konstantin Birukov, M.D., Ph.D.
Research Summary
Dr. Birukov’s laboratory addresses molecular mechanisms
involved in the regulation of lung vascular permeability under
physiological and pathological conditions associated with
ventilator-induced lung injury or bacterial lypopolysacharide-induced
inflammation, including 1) Role of small GTPases Rac and Rho in
magnitude-dependent regulation of lung endothelial cytoskeleton and
permeability; 2) Evaluation of the Rac and Rho effectors within the
focal adhesions and adherens junctions involved in mechanochemical
regulation of vascular permeability; 3) Novel barrier-protective and
anti-inflammatory effects of oxidized phospholipids on the lung
endothelium in acute lung injury.
Selected Papers
Birukova AA, Chatchavalvanich S, Rios S, Kawkitinarong K, Garcia JGN,
Birukov KG. Differential regulation of pulmonary endothelial monolayer
integrity by varying degrees of cyclic stretch. Am J Pathol,
168(5):1749-61, 2006.
Nonas S, Miller I, Kawkitinarong K, Chatchavalvanich K, Gorshkova I,
Bochkov VN, Leitinger N, Natarajan V, Garcia JGN, Birukov KG. Oxidized
phospholipids reduce vascular leak and inflammation in rat model of
acute lung injury. Am J Resp Crit Care Med, 173(10):1130-8, 2006.
Birukova AA, Malyukova I, Poroyko V, Birukov KG. Paxillin - -catenin
interactions are involved in Rac/Cdc42-mediated endothelial
barrier-protective response to oxidized phospholipids. Am J Physiol
Lung Cell Mol Physiol, 293(1):L199-211, 2007.
Birukova AA, Zagranichnaya T, Fu P, Alekseeva E, Chen W, Jacobson JR,
Birukov KG. Prostaglandins PGE2 and PGI2 promote endothelial barrier
enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell
Res, 313(11):2504-20, 2007.
Birukova AA, Alekseeva E, Mikaelyan A, Birukov KG. HGF protects human
pulmonary endothelial barrier via Tiam1/Rac-dependent inhibition of Rho
pathway. FASEB J, 21(11):2776-86, 2007.
Birukova AA, Malyukova I, Mikaelyan A, Fu P, and Birukov KG. Tiam1 and
PIX mediate Rac-dependent endothelial barrier protective response to
oxidized phospholipids. J Cell Physiol, 211(3):608-17, 2007.
Birukova AA, Fu P, Chatchavalvanich S, Burdette D, Oskolkova O, Bochkov
VN, Birukov KG. Polar head groups are important for barrier protective
effects of oxidized phospholipids on pulmonary endothelium. Am J
Physiol Lung Cell Mol Physiol. 292(4):L924-35, 2007.
Birukova AA, Chatchavalvanich S, Oskolkova O, Bochkov VN, Birukov KG.
Signaling pathways involved in OxPAPC-induced pulmonary endothelial
barrier protection. Microvasc. Res., 73(3):173-81, 2007.
Papaiahgari, S, Yerrapureddy, A, Hassoun, PM, Garcia, JGN, Birukov, KG,
and Reddy, S.P. EGFR- Activated signaling and actin remodeling
regulate cyclic stretch-induced NRF2-ARE activation. Am. J. Resp.
Cell Mol. Biol, 36(3):304-12, 2007.
Invited Reviews
Bochkov VN, Leitinger N, Birukov KG.
Role of oxidized phospholipids in acute lung injury. Curr Resp Med Rev,
2:27-37, 2006.
Birukov KG. Oxidized lipids: the two faces of vascular inflammation.
Curr Atheroscler Rep, 8(3):223-231, 2006.
Birukov KG. Cyclic stretch, reactive oxygen species and vascular
remodeling. Antioxidants & Redox Signaling , in press, 2007.
|
Faculty and Research
Programs
|
