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Appointments:
Assistant Professor
Department of Surgery
Committee on Molecular Medicine/MPMM
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Education:
Ph.D., Northwestern
University 2003
M.S., University of Texas at
Austin 1998
B.S., Rice
University 1995
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Contact:
Phone: (773) 834-4161
Fax: (773)
834-4546
E-Mail:
jcollier@surgery.bsd.uchicago.edu
Address:
The University of Chicago
Abbott 522, (MC 5032)
5841 South Maryland Avenue
Chicago, Illinois 60637
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Related Research Interests:
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Joel Collier, Ph.D.
Molecular Biomaterials for Tissue Repair
Research Summary
Research
in our laboratory focuses on designing novel synthetic biomaterials and
investigating how they may be engineered to direct biological
processes. We are particularly interested in understanding how
assemblies of proteins, peptides, polymers, and conjugates of these
molecules can be constructed into synthetic extracellular matrices
capable of directing cell behavior in vitro (e.g. as defined 3-D
culture media) or in vivo (e.g. as scaffolds for Regenerative
Medicine). Our research questions center around three interconnected
areas:
1) Investigating structure-function relationships that determine how
molecular design impacts folding and assembly into nanostructures
(fibrils, networks, and gels), and how the physical, chemical,
mechanical, and biological properties of the assembled material may be
subtly modulated through choices in molecular design.
2) Understanding how cells interact with defined synthetic
extracellular matrices so that the matrices can be systematically tuned
to favor particular cell phenotypes.
3) Understanding how molecular design and assembly state directs
tissue-level or organism-level responses. We are primarily interested
in understanding how assemblies of peptides and proteins engage
inflammatory and immune responses so that they can be engineered to
modulate these processes locally. Although these questions and
approaches are applicable to many tissues, we are currently focusing on
epithelial and endothelial tissues, as these tissues mediate the
interfaces of physiology.
Selected Papers
R.C.
Thomson, G.G. Giordano, J.H. Collier, S.L.
Ishaug, A.G. Mikos, D. Lahiri-Munir, C.A. Garcia, “Manufacture and
Characterization of Poly(alpha-hydroxy ester) Thin Films as Temporary
Substrates for Retinal Pigment Epithelium Cells,” Biomaterials
17(3),
321-327 (1996).
J.H.
Collier, J.P. Camp, T.W. Hudson, C.E.
Schmidt, “Synthesis and Characterization of Polypyrrole/ Hyaluronic
Acid
composites for peripheral nerve regeneration,” Journal of
Biomedical
Materials Research 50(4), 574-84 (2000).
J.H. Collier, B.H. Hu, J.W. Ruberti, J. Zhang, P. Shum, D. H. Thompson,
and
P.B. Messersmith, “Thermally and Photochemically Triggered
Self-Assembly of
Peptide Hydrogels,” Journal of the American Chemical Society,
123,
9463-9464 (2001).
J.H.
Collier and P.B. Messersmith, “Phospholipid
Strategies in Biomineralization and Biomaterials Research,” Annual
Reviews
of Materials Science, 31, 237-63 (2001).
C.H.
Thomas, J.H. Collier, C.S. Sfeir, and K.E.
Healy, “Engineering Gene Expression and Protein Synthesis by Modulation
of
Nuclear Shape,” Proceedings of the National Academy of Sciences,
USA,
99(4), 1972-1977 (2002).
J. H.
Collier and P. B. Messersmith, “Enzymatic
Modification of Self-Assembling Peptide Structures with Tissue
Transglutaminase,” Bioconjugate Chemistry, 14 (4), 748-755
(2003).
J. H.
Collier and P. B. Messersmith,
“Nanostructural Tailoring of Self-Assembled Peptide Structures,” Advanced
Materials, 16 (11), 907-910 (2004).
J. H.
Collier and M. Mrksich, “Engineering a
Biospecific Communication Pathway Between Cells and Electrodes,” Proceedings
of the National Academy of Sciences, USA, 103 (7), 2021-2025
(2006).
P. Jing,
J.P. Jung, and J.H. Collier, “Nanostructured
Materials Constructed from Polypeptides,” in Nanoscience and its
Applications
in Biomedicine, D. Shi, Editor, Springer-Verlag, 2008 (in press).
Jung, J.
P.; Jones, J. L.; Cronier, S. A.;
Collier, J. H., Modulating the mechanical properties of self-assembled
peptide
hydrogels via native chemical ligation. Biomaterials, 29, (13)
2143-2151
(2008).
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