Dianne Deplewski, M.D.

Role of Amino-Terminus of PPAR Gamma in Adipogenesis

Research Summary

Our laboratory is currently pursuing three lines of research. The primary focus is understanding the role of peroxisome proliferators-activated receptors (PPARs) and their importance in stimulating lipogenesis. For this research, I have recently received a Mentored Clinical Scientist Development Award (K08) entitled “The Role of PPAR Gamma Amino-Terminus in the Adipocyte.” The focus is to do mutational analysis of this locus and study the effect in transgenic mice related to the phosphorylation of this amino terminal domain. I am interested in looking at insulin signaling through mutations of the phosphorylation site of this PPAR isoform, which is essential for fat cell development.

Selected Papers

Deplewski D, Liao S, Rosenfield RL. (1997). Preputial sebocyte 5α-reductase isozyme specificity. Endocrinology. 138:4416-4420.

Rosenfield RL, Kentsis A, Deplewski D, Ciletti N. (1999). Rat preputial sebocyte differentiation involves peroxisome proliferator-activated receptors. J Invest Dermatol. 112:226-232.

Deplewski D, Rosenfield RL. (1999). Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinology. 140:4089-4094.

Kim M-J, Deplewski D, Ciletti N, Michel S, Reichert U, Rosenfield RL. (2001). Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development. Mol Genet Metab, 74:362-369.