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Appointments:
Professor and Chairman
Department of Neurology
Committee on Molecular Medicine/MPMM
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Education:
M.D., University of Chicago, 1983
Ph.D., University of Chicago, 1981
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Contact:
Phone: (773) 702-6390
Fax:
(773) 702-5670
E-Mail: cgomez@neurology.bsd.uchicago.edu
Address:
The University of Chicago
AMB S237 (MC 2030)
5841 South Maryland Avenue
Chicago, Illinois 60637
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Related Research Interests:
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Christopher M. Gomez, M.D., Ph.D.
Molecular and Genetic Causes of Neurodegenerative
Disease
Research Summary
Dr. Gomez's research program concentrates on the molecular and cellular
mechanisms of neurodegenerative disease, with a particular focus on the
means by which genetic mutations in ion channels or orther essential
proteins lead to dominantly inherited neurodegenerative diseases.
His laboratory pursues two primary project avenues, one on the genetics
and pathogenesis of the slow-channel syndrome, a model disease of
excitatory synaptic degeneration, the other representing a similar
focus on genetically-determined spinocerebellar ataxias and the
correlatons between ataxia genotype and neurological phenotype.
Selected Papers
Restituito S, Thompson RM, Eliet J, Raike RS, Riedl M, Charnet P, Gomez
CM. (2000). The polyglutamine expansion in spinocerebellar ataxia type
6 causes a beta subunit-specific enhanced activation of P/Q-type
calcium channels in Xenopus oocytes. J Neurosci., 20(17):6394-403.
Gomez CM, Maselli RA, Vohra BP, Navedo M, Stiles JR, Charnet P, Schott
K, Rojas L, Keesey J, Verity A, Wollmann RW, Lasalde-Dominicci J.
(2002). Novel delta subunit mutation in slow-channel syndrome causes
severe weakness by novel mechanisms. Ann Neurol., 51(1):102-12.
Gomez CM, Maselli RA, Groshong J, Zayas R, Wollmann RL, Cens T, Charnet
P. (2002). Active calcium accumulation underlies severe weakness in a
panel of mice with slow-channel syndrome. J Neurosci., 22(15):6447-57.
Subramony SH, Schott K, Raike RS, Callahan J, Langford LR, Christova
PS, Anderson JH, Gomez CM. (2003).
Novel CACNA1A mutation causes febrile episodic ataxia with interictal
cerebellar deficits. Ann Neurol., 54(6):725-31
Gomez CM. (2004). ARSACS goes global. Neurology, 62(1):10-1.
Bushara KO, Nance M, Gomez CM. (2004). Antigliadin antibodies in
Huntington's disease. Neurology, 13;62(1): 132-3.
Maschke M, Gomez CM, Ebner TJ, Konczak J. (2004). Hereditary cerebellar
ataxia progressively impairs force adaptation during goal-directed arm
movements. J Neurophysiol., 91(1): 230-8.
Vohra BPS, Groshong JS, Maselli RA, Verity MA, Wollmann RL, Gomez CM.
(2004). Focal caspase activation underlies the endplate myopathy in
slow-channel syndrome (p 347-352)
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Faculty and Research
Programs
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