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Haochu Huang, Ph.D.
B Cell Tolerance and Activation in Autoimmunity
Research Summary
Dr. Huang’s laboratory is
interested in the roles of autoreactive B
cells and the regulation of B cell tolerance in autoimmune diseases.
Current areas of interest include studying the interactions of
autoreactive T cells and autoreactive B cells, the influence of genetic
background on B cell tolerance and the signaling pathways in B cells
leading to tolerance.
Selected Papers
Huang H, Marsh-Armstrong N and Brown DD. (1999) Metamorphosis is
inhibited in transgenic Xenopus laevis tadpoles that overexpress type
III deiodinase. Proc. Natl. Acad. Sci. USA, 96(3):962-7.
Marsh-Armstrong N, Huang H, Berry DL and Brown DD. (1999) Germ-line
transmission of transgenes in Xenopus laevis. Proc. Natl. Acad.
Sci. USA, 96(25): 14389-14393.
Marsh-Armstrong N, Huang H, Remo BF, Liu T and Brown DD. (1999)
Asymmetric growth and development of the Xenopus laevis retina during
metamorphosis is controlled by type-III deiodinase. Neuron, 24:
871-878.
Huang H and Brown DD. (2000) Overexpression of Xenopus laevis growth
hormone stimulates growth of tadpoles and frogs. Proc. Natl.
Acad. Sci. USA, 97(1): 190-194.
Huang H and Brown DD. (2000) Prolactin is not a juvenile hormone in
Xenopus laevis metamorphosis. Proc. Natl. Acad. Sci. USA, 97(1):
195-199.
Huang H, Cai L, Remo BF and Brown DD. (2001) Timing of metamorphosis
and the onset of the negative feedback loop between the thyroid gland
and the pituitary is controlled by type II iodothyronine deiodinase in
Xenopus laevis. Proc Natl Acad Sci USA. 98(13):7348-53.
Schreiber AM, Das B, Huang H, Marsh-Armstrong N and Brown DD. (2001)
Diverse developmental programs of Xenopus laevis metamorphosis are
inhibited by a dominant negative thyroid hormone receptor. Proc Natl
Acad Sci USA.98 (19):10739-44.
Das B, Schreiber AM, Huang H and Brown DD. (2002) Multiple thyroid
hormone-induced muscle growth and death programs during metamorphosis
in Xenopus laevis. Proc Natl Acad Sci USA 99(19):12230-5.
Maccioni M, Zeder-Lutz G, Huang H, Ebel C, Gerber P, Hergueux J,
Marchal P, Duchatelle V, Degott C, van Regenmortel M, Benoist C and
Mathis D. (2002) Arthritogenic monoclonal antibodies from K/BxN mice. J
Exp Med 195(8):1071-7.
Huang H, Kearney JF, Grusby M, Benoist C and Mathis D. (2006) Induction
of tolerance in arthritogenic B cells with receptors of differing
affinity for self-antigen. Proc Natl Acad Sci USA 103(10): 3734-9.
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