Stephen Meredith, M.D., Ph.D.

Studying the Structure of Beta-amyloid Fibrils Using a Combination of Solution and Solid-state NMR, and Other Physical Methods, Notably Neutron and X-ray Scattering

Research Summary

Selected Papers

Papers in 2009:
Bockhorn JJ, Lazar KL, Gasser A, Luther LM, Qahwash IM, Chopra N, and Meredith SC, Novel Semi-synthetic Method for Generating Full Length β-Amyloid Peptides, submitted, Biopolymers.

Lanning JD and Meredith SC, Chaperone-like N-methyl Peptide Inhibitors of Polyglutamine Aggregation, submitted, Biochemistry.

Paravastu AK, Qahwash IM, Leapman RD, Meredith SC and Tycko R, Seeded growth of synthetic β-amyloid fibrils from Alzheimer’s brain-derived fibrils produces a novel fibril structure, Proc. Natl. Acad. Sci. USA. 106:7443-7448, 2009

Darnell GD, Derryberry JM, Kurutz JW, and Meredith SC, Flanking Polyprolines Induce Polyglutamine Aggregation as PPII Helices Through the Hydrophobic Effect, Biophys J. 97:2295-2305, 2009.

Chopra N, Gan W, Schreiber H, Kurutz JW, and Meredith SC. A Versatile Cyclic Template for Assembly of Peptides and Proteins, Bioconj. Chem. 20: 231-40, 2009.

Sciarretta KL, Orgel JPRO, Tycko R, and Meredith, SC. Evidence for Novel β-Sheet Structure in Iowa Mutation β-Amyloid Fibrils, Biochemistry 48:6072-6084, 2009.

Select Earlier Papers:
Lazar KL, Kurutz JW, Tycko R, Meredith SC, Encapsulation and NMR on an aggregating peptide before fibrillogenesis, J Am Chem Soc. 128:16460-16461, 2006.

Sciarretta KL, Gordon DJ, Meredith SC, Peptide-based inhibitors of amyloid assembly, Methods Enzymol. 413: 273-312, 2006.

Schietinger A, Philip M, Yoshida BA, Azadi P, Liu H, Meredith SC, Schreiber H, A mutant chaperone converts a wild-type protein into a tumor-specific antigen, Science 314: 304-308, 2006.

Gordon DJ, Balbach JJ, Tycko R and Meredith SC. (2004) Increasing the Amphiphilicity of an Amyloidogenic Peptide Changes the β-Sheet Structure in the Fibrils from Antiparallel to Parallel. Biophys. J., 86: 428-434.

Selected as New and Notable:
Liming Hou and Michael G. Zagorski. (2004) Sorting Out the Driving Forces for Parallel and Antiparallel Alignment in the A-beta Peptide Fibril Structure , Biophys. J. 86: 1-2.

Lazar KL, Miller-Auer H, Getz GS, Orgel JP, Meredith SC, Helix-turn-helix peptides that form α-helical fibrils: turn sequences drive fibril structure, Biochemistry 44:12681-12689, 2005.

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