Mark Musch, Ph.D.

Research Summary

Dr. Musch’s research focuses on intestinal epithelial physiology. One facet addresses the identification and regulation of transport proteins for electrolytes as well as non-electrolyte solutes. He is particularly interested in identifying proteins which associate with intestinal sodium/hydrogen exchangers. He is also interested in identifying anion exchangers of intestinal Cl absorption and the role of anion exchangers in volume regulation. Another interest is the roles of stress proteins in the intestine as protective agents in intestinal inflammation and damage. The inflammatory as well as environmental cues which regulate their expression are also being investigated.

Selected Papers

Musch MW, Petrof EO, Kojima K, Ren Hongyu, McKay D, and Chang EB. (2004). Bacterial superantigen treated intestinal epithelia upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity. Infec Immun 72: 3187-3194.

Zhao H, Shiue H, Palkon S, Yang Y, Cullinan P, Burkhardt JK, Musch MW, Chang EB, and Turner JR. (2004). Ezrin regulates NHE3 translocation and activation after Na+- glucose cotransport. PNAS 110: 9485-9490.

Musch MW, Koomoa DL, and Goldstein L. (2004). Hypotonicity-induced exocytosis of the skate anion exchanger skAE1: role of lipid raft regions. J Biol Chem 279 39447-39453.

Vavricka SR, Musch MW, Chang JE, Nakagawa Y, Phanvijhitsiri K, Waypa TS, Merlin D, Schneewind O, and Chang EB. (2004). hPepT1 transports muramyl dipeptide, activating NF-kB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology 127: 1401-1409.

Petrof EO, Kojima K, Ropeleski MJ, Musch MW, Tao Y, De Simone C, and Chang EB. (2004). Probiotics inhibit NF-kB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology 127: 1474-1487.

Arvans D, Vavricka SR, Ren H, Musch MW, Kang L, Rocha F, Lucioni A, Alverdy J, Turner J, and Chang EB. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock protein 25 and 72. Am J Physiol (in press).

Shiue H, Yingman W, Musch MW, Chang EB and Turner JR. Akt2 phosphorylates exrin to trigger NHE3 translocation and activation. J Bio Chem (in press)

Wu L, Estrada O, Zaborina O, Kohler JE, Le S, Musch MW, Chang EB, Fu Y, Olson M, Jacobs M, Nishimura M, Turner JR and Alverdy JC. Recognition of host immune activation by Pseudomonas aeruginosa: role of interferon - gamma. Science (submitted)