Viswanathan Natarajan, Ph.D.

The Role of NADPH Oxidase Sub-componets and its Homologs in Production of Reactive Oxygen Species Leading to Vascular Leakiness and Crosstalk Between G-protein Coupled Receptors and Growth Factor Receptors in Lysophosphatidic Acid Mediated Cytokine Secretion and Innate Immunity

Research Summary

Dr. Natarajan is a well established and leading investigator on vascular biology, oxidant-induced lung injury, mechanisms of regulation of phospholipases A2 and D and generation of lipid second messengers such as oxygenated derivatives of arachidonic acid, phosphatidic acid and lysophosphatidic acid in the lung and role of bioactive lipids as modulators of airway inflammation and endothelial cell homeostasis. Dr. Natarajan’s laboratory has been actively investigating the role of NADPH oxidase sub-components and its homologs in production of reactive oxygen species leading to vascular leakiness and cross-talk between G-protein coupled receptors and growth factor receptors in lysophosphatidic acid mediated cytokine secretion and innate immunity. This translational research will lead to development of novel therapeutic interventions to reduce airway inflammation and pulmonary edema.

Selected Papers