Jose Quintans, M.D., Ph.D.

Apoptosis; Autoimmunity

Research Summary

Selected Papers

Bergmann BM, Rechtschaffen A, Gilliland MA, Quintans J. (1996). Effect of extended sleep deprivation on tumor growth in rats. Am J Physiol. 271(5 Pt 2):R1460-4.

Chmura SJ, Nodzenski E, Beckett MA, Kufe DW, Quintans J, Weichselbaum RR. (1997). Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res. 57(7):1270-5.

Wiesner DA, Kilkus JP, Gottschalk AR, Quintans J, Dawson G. (1997). Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-XL. J Biol Chem. 272(15):9868-76.

Chmura SJ, Mauceri HJ, Advani S, Heimann R, Beckett MA, Nodzenski E, Quintans J, Kufe DW, Weichselbaum RR. (1997). Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res. 57(19):4340-7.

Chmura SJ, Nodzenski E, Kharbanda S, Pandey P, Quintans J, Kufe DW, Weichselbaum RR. (2000). Down-regulation of ceramide production abrogates ionizing radiation-induced cytochrome c release and apoptosis. Mol Pharmacol. 57(4):792-6.