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Appointments:
Associate Professor
Department of Medicine
Section of Hematology/Oncology
Director, Thoracic Oncology
Research Program
Committee on Cancer Biology
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Education:
MD, Loyola University, 1987
PhD, Loyola University, 1985
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Contact:
Phone: (773) 702-4399
Fax: (773)
834-0188
E-Mail: rsalgia@medicine.bsd.uchicago.edu
Address:
The University of Chicago
AMB M255, (MC 2115)
920 East 58th Street
Chicago, Illinois 60637
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Related Research Interests:
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Ravi Salgia, M.D., Ph.D.
Translational Research in Upper Aerodigestive Tract
Cancers
Research Summary
Dr. Salgia’s expertise is in the area of thoracic oncology,
translational research and basic science research. His main research
interest is to arrive at novel targeted therapeutics to enhance the
quality of life and survival for patients with cancer. He and his lab
have recently identified several novel receptor tyrosine kinases that
are abnormal in lung cancer. He is an expert in signal transduction, as
related to growth factor receptors and oncogenes/tumor suppressor
genes, and is developing novel inhibitors based on these pathways. He
is also an expert in tumor and body fluid biomarkers, and is applying
this knowledge to develop new serum/tumor tissue tests for thoracic
oncology.
Selected Papers
Salgia
R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y, Pisick E,
Hallek M, Ernst T, Tantravahi R, Chen LB, Griffin JD. (1995). Molecular
cloning
of human paxillin, a focal adhesion protein phosphorylated by
p210BCR/ABL. J Biol Chem 270:5039-5047.
Wang
WL, Healy ME, Sattler M, Verma S, Lin J, Maulik G, Stiles CD, Griffin
JD, Johnson BE, Salgia R. (2000). Growth inhibition and modulation of
kinase
pathways of small cell lung cancer cell lines by the novel tyrosine
kinase inhibitor STI 571. Oncogene. 19(31): 3521-3528.
Salgia
R, Lynch T, Skarin A, Lucca J, Lynch C, Jung K, Hodi FS, Jaklitsch M,
Mentzer S, Swanson S, Lukanich J, Bueno R, Wain J, Mathiesen D, Wright
C, Fidias P, Donahue D, Clift S, Hardy S, Neuberg D, Mulligan R, Webb
I, Sugarbaker D, Mihm M, and Dranoff G. (2003). Vaccination with
irradiated
autologous tumor cells engineered to secrete granulocyte-macrophage
colony-stimulating factor augments antitumor immunity in patients with
metastatic non-small-cell lung carcinoma. J Clin Oncol. 21(4): 624-630.
Ma
PC, Kijima T, Maulik G, Fox EA, Sattler M, Griffin JD, Johnson BE, and
Salgia R. (2003). c-MET mutational analysis in small cell lung cancer:
novel
juxtamembrane domain mutations regulating cytoskeletal functions.
Cancer Research. 63(19): 6272-6281.
Sattler
M, Pride YB, Ma P, Gramlich JL, Chu SC, Quinnan LA, Shirazian S, Liang
C, Podar K, Christensen JG, Salgia R. (2003). A novel small molecule
met
inhibitor induces apoptosis in cells transformed by the oncogenic
TPR-MET tyrosine kinase. Cancer Res. 63(17): 5462-9.
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Faculty and Research
Programs
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