The Committee on Immunology - Laboratories
With over thirty laboratories covering the most
exciting areas of basic and applied immunology, the
Committee on Immunology offers some of the finest training
opportunities in the country. Read on for a tour of Immunological
Research Foci at The University of Chicago.
The cellular capture and processing of antigens and their presentation
to T lymphocytes is a carefully regulated process that is central to
immunity. Our faculty is making seminal contributions to understanding
the function of classical MHC molecules in peptide presentation as well
as the novel area of CD1 presentation of lipid antigens and H2-M3
presentation of formylated bacterial peptides. Albert
Bendelac, Sasha Chervonsky, Marcus Clark, Jose Guevara, Chyung-Ru Wang.
Autoimmunity, Immunopathology. When immunity
goes awry, multiple immune diseases can create illness and death. Our
faculty is world-renowned in the areas of Celiac Disease and
Inflammatory Bowel Diseases, Lupus, Multiple Sclerosis, Rheumatoid
Arthritis, Type I (autoimmune) Diabetes. Marisa Alegre,
Albert Bendelac, Sasha Chervonsky, Marcus Clark, Yang-Xin Fu, Bana
Jabri, Anthony Reder, Raymond Roos, Anne Sperling, Martin Weigert, Jian
Infection Immunity. Immunity evolved to
combat pathogens and harmful agents. Understanding the mechanisms of
host defense to pathogens, and the mode of action of vaccines and
vaccine adjuvants is critical to treatment and vaccine
development. Albert Bendelac, Sasha Chervonsky, Tatyana
Golovkina, Bana Jabri, Rima McLeod, Glenn Randall, Raymond Roos,
Hematopoisis, Lymphoid and Myeloid Development.
Studies of transcriptional control of lineage commitment in hemopoiesis
are at the cutting edge of modern Developmental Biology. Early
â€˜transcriptional networksâ€™ are just being described by
uncovering both the principles and mechanisms of lineage
commitment. Barbara Kee, Kay MacLeod, Harinder Singh.
Signal Transduction in Lymphoid Development and
genetic and biochemical approaches, our faculty publishes landmark
studies of some of the most complex signaling immune receptors
including the pre-B and the B cell antigen receptor, the pre-T and the
T cell antigen receptor, the Natural Killer (NK) receptors, the TNF
receptor, dissecting their functions in cell death or survival,
proliferation, differentiation, effector function. Erin
Adams, Albert Bendelac, Marcus Clark, Thomas Gajewski, Fotini Gounari,
Haochu Huang, Bana Jabri, Vinay Kumar, Marcus Peter, Jian Zhang.
B cell development. Our faculty has a
comprehensive approach to understanding how signaling through the pre-B
cell antigen receptor (pre-BCR) and the BCR directs developmental
stages and coordinates immunoglobulin gene rearrangement, editing,
mutation with lineage decisions, cell survival or death. Marcus
Clark, Karen Frank, Barbara Kee, Harinder Singh, Ursula Storb, Martin
Antigen receptor gene rearrangement, editing, somatic
Our faculty has made seminal contributions to the discovery and
understanding of this most fascinating hallmark of the vertebrate
immune system, the ability to undergo gene rearrangement, hypermutation
and editing to create antigen receptor diversity. Karen
Frank, Haochu Huang, Harinder Singh, Ursula Storb, Martin Weigert.
T Cell Differentiation, T Cell Memory.
Antigen-activated T cells give rise to effector and memory cells.
Appropriate types of effector cells (e.g. IFN-g producing T helper 1 or
IL-4 producing T helper 2) are critical for the clearance of various
intracellular and extracellular pathogens. Vigorous memory formation is
important for protection by vaccines. These processes have major
biomedical implications in tumor and infection immunology as well as
immunopathology. Marisa Alegre, Albert Bendelac, Yang-Xin Fu,
Thomas Gajewski, Fotini Gounari, Bana Jabri, Anne Sperling, Chyung-Ru
Innate immunity. There is growing
evidence that cells and receptors of innate immunity not only provide a
first line of defense against pathogens but also control adaptive
immunity. This new interface between innate and adaptive immunity is
critical to understanding and manipulating tumor immunity, infections,
autoimmunity. Albert Bendelac, Tatyana Golovkina, Bana Jabri,
Glenn Randall, Vinay Kumar.
Mucosal Immunology. The intestine and the
lung mucosal surfaces constitute unique microenvironments that harbor
highly specialized immune systems. Critical to dissecting the
mechanisms of widespread inflammatory diseases such as inflammatory
bowel diseases, celiac disease, and asthma, are the studies on the
development and function of the mucosal immune system by our
faculty. Yang-Xin Fu, Bana Jabri, Anne Sperling.
Transplantation. Barriers to organ
transplantation have been the starting point for some of the major
immunological discoveries of the century. Immunological knowledge now
creates multiple opportunities to develop new medical strategies for
acceptance of transplants across allogeneic and xenogeneic
barriers. Marisa Alegre, Anita Chong.
Tumor immunity. Our faculty has made seminal
contributions to a molecular understanding of cancer antigens.
Ingenious strategies are now being envisioned -and some have already
been implemented- to vaccinate mice in the laboratory as well human
patients, against cancer. Yang-Xin Fu, Thomas Gajewski, Jose
Guevara, Hans Schreiber.
Committee On Immunology